2021-22 EPL Week 1 – Predictions, Betting Tips & Odds

The wait is over, and the opening weekend of the Premier League season is upon us, with the twists and turns that come with top-flight football on the horizon. Manchester City are the defending champions and once again look to be the team to beat in the Premier League, with the likes of Liverpool, Manchester United and Chelsea all sure to be in the mix too. Leicester City, Tottenham and Arsenal are all sides that could have a say at the top of the table too this term whilst for the promoted sides of Brentford, Norwich City and Watford, survival will be key.

Here are our picks for the opening round of fixtures in the Premier League:

All odds are with Sportsbet – our No. 1 rated bookmaker. You can join Sportsbet by clicking HERE.

EPL Week 1 Predictions

Brentford vs Arsenal – Brentford Community Stadium

Brentford ($4.75)

Arsenal ($1.9)

Draw ($3.7)

Promoted side Brentford will get their Premier League adventure underway as they welcome London rivals Arsenal. The Bees came up through the play-offs last season and have been knocking on the door of the Premier League for a while. They will provide a tough test for an Arsenal side that have Mikel Arteta at the helm and with summer acquisition Ben White tasked with sorting out their defensive ranks, they could have an intriguing season ahead. Brentford will give this a proper go, but Arsenal should have too much for them in this one.

Betting tip: Arsenal to win the match ($1.9) – Bet @ Sportsbet

Arsenal to win 2-1

Manchester United vs Leeds United – Old Trafford

Manchester United ($1.6)

Leeds United ($6.4)

Draw ($4.55)

Two sides with no love lost take on each other on the opening day as Leeds United travel across the Pennines to Manchester United. The hosts have signed up Jadon Sancho to their ever growing list of exciting attacking talents and he will be looking to hit the ground running for his new side here. Leeds meanwhile have Marcelo Bielsa at the helm and will feel anything is possible under his stewardship, as they look to build upon their impressive first campaign back in the Premier League last year. This could be a fiery encounter with Manchester United most likely to come out on top.

Betting tip: Manchester United to win the match ($1.6) – Bet @ Sportsbet

Manchester United to win 3-1

Burnley vs Brighton – Turf Moor

Burnley ($3.3)

Brighton ($2.6)

Draw ($3.2)

Two sides with survival on their mind face off as Burnley host Brighton at Turf Moor. Sean Dyche continues to work wonders with the Lancastrians, who will be hoping to pick up points from the outset this term – having endured a tough start to the season last year. Brighton meanwhile have lost Ben White but have been able to pick up some signings of their own as Graham Potter looks to push the Seagulls up the table. This could be a cagey affair at Turf Moor, with both sides eager not to lose and a draw looks the most likely outcome.

Betting tip: The match to finish as a draw ($3.2) – Bet @ Sportsbet

1-1 Draw

Chelsea vs Crystal Palace – Stamford Bridge

Chelsea ($1.3)

Crystal Palace ($15)

Draw ($6.2)

Champions League holders Chelsea take on an all-change Crystal Palace side in what promises to be an intriguing start to the season. The blues have spent big in the summer once more and they will be looking to challenge domestically, after finishing 4th last season and well off the pace. Crystal Palace meanwhile have brought in Patrick Vieira to replace Roy Hodgson and they have a fresh new look to their side and with that, a new brand of football. Chelsea will have to be aware heading into this one, but they are a good side and should prevail here.

Betting tip: Chelsea to win the match ($1.3) – Bet @ Sportsbet

Chelsea to win 2-0

Everton vs Southampton – Goodison Park

Everton ($1.99)

Southampton ($4.3)

Draw ($3.7)

Two sides that will be looking to force their way into the top half of the Premier League face off as Everton host Southampton. The Toffees have Rafa Benitez at the helm and the former Liverpool boss will need to hit the ground running to keep the fans off his back. They are a side with plenty of attacking talents though and he will be looking to temper them. Southampton meanwhile have lost mainstays in their side such as Danny Ings and Ryan Bertrand and they will be desperate to start putting points on the board quickly. Judging where both sides are is tricky at this point, but Everton should prevail here at home.

Betting tip: Everton to win the match ($1.99) – Bet @ Sportsbet

Everton to win 2-1

Leicester City vs Wolves – King Power Stadium

Leicester City ($1.75)

Wolves ($5.7)

Draw ($3.85)

FA Community Shield winners Leicester City will be looking to finish inside the top 4 again this season as they host Wolves. The Foxes had an excellent campaign last year and will be looking to replicate that once more under Brendan Rodgers. Wolves meanwhile will be looking to rebuild under Bruno Lage, following a disappointing campaign that culminated in Nuno Esporito Santo leaving the club to go and manage Tottenham. This could be a tight game but with Leicester seemingly better organised, the Foxes should prevail at home here.

Betting tip: Leicester City to win the match ($1.75) – Bet @ Sportsbet

Leicester City to win 2-1

Watford vs Aston Villa – Vicarage Road

Watford ($3.3)

Aston Villa ($2.55)

Draw ($3.4)

Promoted Watford get their Premier League campaign underway with a tricky looking home tie against Aston Villa. The Hornets were good value in the Championship last term and their exciting brand of football always lights up the Premier League. They host a Villa side that has lost their talisman in Jack Grealish but with the likes of Leon Bailey and Danny Ings brought in as replacements, it promises to be an exciting season at Villa Park. Judging quite where these two sides are at will be a tricky task, making the draw the most plausible result here.

Betting tip: The match to finish as a draw ($3.4) – Bet @ Sportsbet

1-1 Draw

Norwich City vs Liverpool – Carrow Road

Norwich City ($10)

Liverpool ($1.36)

Draw ($6)

Another promoted side will be looking to get their campaign underway as Norwich City host Liverpool. The Canaries bounced straight back up following their relegation in the summer of 2020 and they will be out to prove they have what it takes in the big time. They welcome Liverpool who have high hopes for the campaign ahead, especially if they can keep their key players fit – something they simply couldn’t do throughout last season. It should be a raucous atmosphere at Carrow Road, but Liverpool should have the knowhow to get through with a win.

Betting tip: Liverpool to win the match ($1.36) – Bet @ Sportsbet

Liverpool to win 2-0

Newcastle United vs West Ham United – St James’s Park

Newcastle United ($3.3)

West Ham United ($2.3)

Draw ($3.65)

Two more sides looking to make their way into the top half of the table do battle as Newcastle host West Ham. The Toon continue with Steve Bruce in charge, and they will be looking to build on a decent campaign last year and avoid slipping into any potential relegation trouble. They host a West Ham side being managed superbly by David Moyes, but he and the Hammers faithful know all too well the rigours having to play European football next season will place on them. This could be another tricky game to call on the North East and a draw looks on the cards.

Betting tip: The match to finish as a draw ($3.65) – Bet @ Sportsbet

1-1 Draw

Tottenham vs Manchester City – Tottenham Hotspur Stadium

Tottenham ($5.7)

Manchester City ($1.67)

Draw ($4.3)

Champions Manchester City will be looking to get their campaign off to a winning start as they travel to Tottenham. The hosts will be looking to get going quickly after a poor season last year and keeping hold of Harry Kane could be crucial in terms of their aspirations this term. City will arrive in North London fresh off the back of a Community Shield defeat to Leicester City and with plenty of their key players still building up fitness following Euro 2020. Spurs will be bang up for this and could well end up pinching a point in front of their home fans.

Betting tip: The match to finish as a draw ($4.3) – Bet @ Sportsbet

1-1 Draw

EPL Week 1 multi bet

We’re backing four results this week as a four-leg multi with a betting stake of $50:

Norwich City vs Liverpool – Liverpool to win
Manchester United vs Leeds United – Manchester United to win
Chelsea vs Crystal Palace – Chelsea to win
Leicester City vs Wolves – Leicester City to win

A $50 wager would pay out $237.50 if successful at the current odds – Bet @ Sportsbet

All odds are with Sportsbet – our No. 1 rated bookmaker. You can join Sportsbet by clicking HERE.

Sam Hayes
About the Author: Sam Hayes

Combining his sports coaching career with freelance journalism, Sam is a sports betting writer for various online publications. He is looking to develop both his respective coaching and writing careers, whilst incorporating his other huge passion – travelling the world.
Sam currently lives and works in Milan, Italy and playing/following/writing about cricket, football (soccer), tennis, formula 1 and golf continue to take up much of his spare time.



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