The NFL continues with Week 16 action, and we have NFL expert betting picks and predictions for every game of the year.
Action starts with the Rams vs. Seahawks on Friday, and the featured games this week include Packers vs. Bears, Jaguars vs. Broncos, and Patriots vs. Ravens.
NFL Week 16 Predictions
—
Friday 19/12/25
There is good value in betting the Rams on Friday, and we believe that they should be favourites to win outright.
They look like genuine Super Bowl contenders, and Matthew Stafford has been one of the most impressive quarterbacks. That should be enough for the Rams to have an edge, and the underdog odds are worth taking.
Take the $2.10 before money comes for them on game day.
Rams by 7
—
Sunday 21/12/25
It hasn’t been smooth sailing for the Eagles, but they should cover the spread against the 4-10 Commanders on Sunday morning.
Saquon Barkley and Jalen Hurts need to start playing better football, but if they do, everyone knows what they can deliver.
The –6.5 line is fair, and they should win by a touchdown.
Eagles by 7
—
We’re backing the Bears to get revenge over the Packers, who beat them only two weeks ago at Lambeau Field.
Playing at Soldier Field only helps the Bears, and they have been impressive for the most part this season, especially with Caleb Williams at quarterback.
If they control the pace of play, they should grind out a win over their rivals.
Bears by 3
—
Monday 22/12/25
Coming back from 21-0 down last week against the Patriots was a massive effort from the Bills, and the Browns shouldn’t give them any worries.
There has been no reason to get excited about what the Browns have produced in what has been another long and disappointing season for their fans.
Take the Bills –9.5, in what should be a straightforward win.
Bills by 17
—
Despite dealing with injuries, the Chargers keep finding ways to win, and the Cowboys are arguably lucky to have the record they have.
We can’t back the Cowboys with any amount of confidence, and although Justin Herbert is playing with one arm, he’s still doing enough to win.
Take the underdogs to score a road upset.
Chargers by 6
—
We would advise to stay away from betting this game, but the Titans represent more value at +3.5.
The Chiefs ended their playoff hopes with a loss last week, and losing Patrick Mahomes to injury is likely to close their year on a sour note.
The Titans are terrible, but we’re picking them to win their first home game.
Titans by 1
—
There are suggestions that Joe Burrow is looking for a way out of Cincinnati, but he doesn’t often throw in the towel on the field.
He was disappointing last week in a poor performance, but the Dolphins were equally bad, and they have had no betting support.
We would follow the betting move for the Bengals.
Bengals by 7
—
It won’t be the most popular game of the week, but there is value in betting the Saints on Monday morning.
They have improved to 4-10, which doesn’t sound good, but it was looking much worse for most of the year. The Jets are 3-11, which puts things into perspective.
Take the Saints to win and cover the spread.
Saints by 10
—
Money should come for the Vikings to win and cover the –2.5 spread, which is worth including in NFL multi bets this week.
They might have been a touch disappointing in posting a 6-8 record, but they have more weapons than the struggling Giants, who are 2-12.
Vikings by 7
—
The Panthers have a good chance to make the playoffs, and given how poorly the Buccaneers are playing, we’re loving the odds.
Bookmakers have the Panthers at $2.33 despite playing at home, so we’re jumping on the Panthers to get the job done.
Money should come for them throughout the week.
Panthers by 6
—
The Broncos keep delivering in the big games, and they’re making a serious run towards the NFL playoffs.
Beating the Jaguars, who are playing well, won’t be easy, but punters should have faith in the 12-2 Broncos to get it done.
They are 7-0 at home, which strengthens our confidence.
Broncos by 7
—
It has been a bad year for the Falcons and Cardinals, so they’re playing for pride this week.
We have been more impressed by the Falcons, who haven’t had things go their way, so they deserve another chance.
The –2.5 line is worth including in NFL bets this week.
Falcons by 7
—
Winning games hasn’t been easy for the Lions, but they should knuckle down and beat the Steelers by at least a touchdown.
They are 5-2 at Ford Field, so they have that going for them, and we’re happy with the –6.5 line available with bookmakers.
Jared Goff has been good, so back him and the Lions with confidence.
Lions by 10
—
Betting on the Raiders is akin to throwing money away, so we’re including the Texans –14.5 in our NFL predictions.
They have come alive in the second half of the season to post a 9-5 record, and they should have far too much class for Las Vegas.
The line is big, but it could be over before halftime.
Texans by 21
—
It’s one of the harder games to pick this week, but the Ravens could jump on the Patriots at home.
The Patriots gave up a 21-0 lead against the Bills last week, and that loss could be tough to recover from, especially against a team like the Ravens.
We recommend taking the line before it moves to –3.
Ravens by 3
—
Tuesday 23/12/25
Not much has gone right for the Colts in the second half of the year, but they are good enough to keep it close.
They’re without their starting quarterback in Daniel Jones, but they have a strong running game, which can match the running game of the 49ers.
Playing at home helps, so expect a close finish.
49ers by 3
