Colts vs. Chiefs Predictions - NFL Week 2 2026-27

Starts in 3d 23h

Match Details

Date: Monday, 21 September 2026
Start Time: 10:20 AM (AEST)
Stadium: Arrowhead Stadium

“Sunday Night Football” features the Colts vs. Chiefs on Monday morning, and it should be a great contest. NFL fans were excited to see the return of Patrick Mahomes from injury, and although he wasn’t his dynamic best, the Chiefs were impressive winners. The Colts didn’t fire a shot against the Ravens, which is why the Chiefs are -6.5 favourites to start their season in fine style.

Best Bet

Chiefs -6.5 @ $1.90

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We’re jumping on the -6.5 line before it moves to -7.5 throughout the week, which is likely to happen with a publicly-supported team like the Chiefs.

They looked good when beating the Broncos last week, and even though Mahomes didn’t have his best game, Kenneth Walker III showed why he was a big offseason signing from the Seattle Seahawks. He had a big rushing performance, and he could repeat that against the Colts.

Indianapolis didn’t produce much in a 41-23 loss to the Ravens. It was a dour performance, and we can’t see them being a playoff threat with Daniel Jones at quarterback. He’s not dynamic enough, so they need to rely on Jonathan Taylor at running back to produce positive yards.

With this game being played at Arrowhead, we expect the Chiefs to improve their record to 2-0, and they should get it done by at least one touchdown.

Same Game Multi

Chiefs -6.5, Kenneth Walker III Anytime Touchdown Scorer, Travis Kelce Anytime Touchdown Scorer, Total Points Under 46.5 @ $15.25

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Walker III is paying short odds to score a touchdown, but it’s good enough to boost NFL SGM odds. He comes off a huge debut for the Chiefs, and we don’t see the Super Bowl-winning running back slowing down anytime soon.

Travis Kelce also had a solid opening. He made a big catch in midfield, and he’s a big target for Mahomes in the end zone. We expect him to be targeted, and the $2.90 odds are worth including in NFL picks to boost payouts.

The Colts could struggle to put points on the board, so under 46.5 points is a good bet.

Best Value Bet

Kenneth Walker III Most Rushing Yards @ $2.20

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Taylor is the current $1.63 favourite to have the most rushing yards, but Walker III only needs to replicate his Week 1 performance to win this bet.

He broke through the defence with ease against the Broncos, who have a good defence, so he could do the same against a Colts team that allowed the Ravens to score 41 points.

$2.20 for Walker III to have the most rushing yards is a value bet.

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Editor In Chief

Daryl Curnow

After graduating from the University of Auckland (BA - English), Daryl Curnow was thrown into the world of sports and horse racing journalism.

Having worked as a racing journalist for two years, he decided to move into the online world of horse racing and sports writing. After years of honing his craft, Daryl became a professional punter in 2009 - with a focus on horse racing, NRL, AFL, NBA, Rugby, NFL, and US college sports.

Daryl's tips have been featured on various websites around the world before joining the GoBet team. When he's not working, Daryl tries to avoid making bogeys on the golf course.