Cowboys vs. Panthers Predictions – NRL Round 10 2025

The Cowboys vs. Panthers headlines NRL Round 10 action on Saturday May 10 at 7:35pm, and we have Cowboys vs Panthers predictions.

It might only be Round 10, but it’s a crucial game for both teams, and there has been plenty of action with NRL odds.

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Cowboys vs. Panthers Predictions

Best Bet

Panthers -3.5 @ $1.90

The Panthers showed why they’re four-time NRL champions with a one-sided win over the Broncos in Magic Round.

A loss would have made it hard for them to make the playoffs, but the win keeps them in the hunt, and we’re backing them to keep winning against the Cowboys, which has been their bogey team over the last two years.

The Panthers are 0-2 in the last two against the Cowboys, including a 22-18 loss earlier this year. However, with more confidence following a 32-8 win, the Panthers are good enough to win and cover the –3.5 spread.

The Cowboys have exceeded expectations so far, and the Panthers should only continue to improve.

Same Game Multi

Panthers –3.5, Brian To’o Anytime Try Scorer, Paul Alamoti Anytime Try Scorer, Under 49.5 @ $10.25

Our same game multis include two Panthers’ try scorers, with Brian To’o and Paul Alamoti featuring in our picks.

To’o has four tries in his last five games, and although he didn’t score last week, he should look to improve his form as State of Origin approaches. That’s usually when he starts scoring, and he’s the current $1.64 favourite to score.

Alamoti hasn’t been consistent, having not scored in four of his last five games, but that was more to do with not getting good ball from the halves. We’re hoping Nathan Cleary is back to his best because Alamoti should cash in if he is.

Under 49.5 is one of our more confident picks. They scored totals of 40 and 22 points from their last two meetings, so it should be a lower scoring game than bookmakers expect. Our score line prediction is Panthers 26-20.

Best Value Bet

Brian To’o First Try Scorer @ $8.00

This could be the game when To’o breaks out for a big performance, and we’re backing him to score the opening try on Saturday night.

He is one of the toughest wingers in the NRL, and a lot of his work is bringing the ball off the line. However, he’s a silky-smooth finisher, and Cleary should want to get him involved early in the game to get his confidence up.

Punters get $8, so it’s worth the risk.

Daryl Curnow

About Daryl Curnow

After graduating from the University of Auckland (BA - English), Daryl was thrown into the world of sports and horse racing journalism. Having worked as a racing journalist for two years, he decided to move into the online world of horse racing and sports writing. After years of honing his craft, Daryl became a professional punter in 2009 - with a focus on horse racing, NRL, AFL, NBA, Rugby, NFL, and US college sports. Daryl's tips have been featured on various websites around the world before joining the GoBet team. When he's not working, Daryl tries to avoid making bogeys on the golf course.

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