Chiefs vs. Chargers Predictions – NFL Week 1 2025

We have Chiefs vs. Chargers predictions for Week 1 of the NFL, where Sao Paolo in Brazil hosts Patrick Mahomes and the Chiefs against the Los Angeles Chargers on Saturday September 6 at 10.00 am.

Money has come for the Chargers to score an upset win, but the Chiefs are always a good bet in Week 1.

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Chiefs vs. Chargers Predictions

Best Bet

Chiefs –3.5 @ $2.03

We love backing the Chiefs in the opening round as they rarely let us down, so there’s no reason to jump off their back.

Having Mahomes at the helm is always good, and we often find the Chargers being overrated in the opening few weeks. Expectations are always high for the Chargers, but they rarely deliver, so we’re not interested in backing them at $2.42.

A Super Bowl run is possible for the Chiefs, who should have more fans in Brazil than the Chargers. That could be enough to see the Chiefs win by at least a touchdown. There is a lot of points in the Chiefs, so winning by double-digits isn’t a hard ask.

Same Game Multi

Chiefs –3.5, Xavier Worthy Anytime Touchdown Scorer, Patrick Mahomes 225+ Passing Yards, Over 45.5 Points @ $7.50

It could be a big year for Xavier Worthy as the primary target for the Chiefs. He should link up with Mahomes on many occasions, and he could get off to a fast start on Saturday with a touchdown.

Punters get $2.40 for Worthy to score a touchdown, which is worth including in NFL Week 1 picks this week. He scored six touchdowns last year, which was marred by injury, and he could return in fine form.

We also like Patrick Mahomes over 225 passing yards. It should be ideal conditions for a big passing game, and he’s still one of the elite passing quarterbacks in the NFL. It’s a generous line with NFL odds, so include it in multis.

Best Value Bet

Chiefs Halftime/Fulltime @ $2.20

We would have been happy with $2 for the Chiefs halftime/fulltime, so getting $2.20 makes it a value pick on Saturday.

The Chiefs have an ability to score points on any drive, and although the Chargers have a good team on paper, they typically disappoint on game day. Justin Herbert has the arm, but not the heart of an elite quarterback.

Look for Mahomes to put points on the board early and never look back.

For betting on our expert NFL tips, we recommend checking out our top Australian bookmakers, recommended betting sites, and top betting apps.

Daryl Curnow

About Daryl Curnow

After graduating from the University of Auckland (BA - English), Daryl was thrown into the world of sports and horse racing journalism. Having worked as a racing journalist for two years, he decided to move into the online world of horse racing and sports writing. After years of honing his craft, Daryl became a professional punter in 2009 - with a focus on horse racing, NRL, AFL, NBA, Rugby, NFL, and US college sports. Daryl's tips have been featured on various websites around the world before joining the GoBet team. When he's not working, Daryl tries to avoid making bogeys on the golf course.

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