Cowboys vs. Eagles Predictions – NFL Week 1 2025

We have Cowboys vs. Eagles predictions for the opening game of the NFL season on Friday September 5 at 10:21 am, where last season’s Super Bowl winners are the firm favorites at home.

The Eagles are $1.25 favorites to handle the Cowboys, who have had off-season troubles, and it could be another long year for them.

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Cowboys vs. Eagles Predictions

Best Bet

Eagles –7.5 @ $1.90

The Eagles have been well-backed to win the Super Bowl, and although we’re not picking a repeat performance, they should take care of the Cowboys with ease on Friday afternoon.

The Cowboys traded away their best defender, and with quarterback Dak Prescott struggling to find open receivers, the Eagles shouldn’t be worried about needing too many points to win and cover the –7.5 spread.

Boasting Jalen Hurts at QB and Saquon Barkley at running back, the Eagles are well-placed to win. Barkley could have a massive game, and we expect him to slice through the Cowboys defence like paper. The Eagles have too many weapons, so back them to cover the –7.5 spread.

Same Game Multi

Eagles –7.5, Saquon Barkley Anytime Touchdown Scorer, Saquon Barkley 90+ Rushing Yards, Under 47.5 Points @ $6.50

It should be a statement game for Barkley, who we’re backing to score a touchdown and have 90+ rushing yards.

The former New York Giants’ RB comes off a big year, where he stayed relatively injury-free. That’s a big thing for Barkley, who should fancy his chances of posting a big rushing total. 90 yards isn’t hard for him, especially given how much ball he will get.

He’s also a threat close to the end zone, and the $1.55 odds for Barkley to score a touchdown is an excellent price. He will force his way for a touchdown, so take the odds before they shorten.

We can’t see Dallas scoring a big total, so under 47.5 points is worth including in NFL picks this week.

Best Value Bet

Saquon Barkley First Touchdown Scorer @ $5.25

Why not back Barkley to score the opening touchdown? He’s the biggest threat to score in the opening NFL game of the year, and the $5.25 odds are worth including in NFL picks.

He will be used heavily by the Eagles in all situations. He can break through the defence for a big running play, or he can be used in short yardage plays.

Take the value odds for Barkley to get his season off to a big start.

For betting on our expert NFL tips, we recommend checking out our top Australian bookmakers, recommended betting sites, and top betting apps.

Daryl Curnow

About Daryl Curnow

After graduating from the University of Auckland (BA - English), Daryl was thrown into the world of sports and horse racing journalism. Having worked as a racing journalist for two years, he decided to move into the online world of horse racing and sports writing. After years of honing his craft, Daryl became a professional punter in 2009 - with a focus on horse racing, NRL, AFL, NBA, Rugby, NFL, and US college sports. Daryl's tips have been featured on various websites around the world before joining the GoBet team. When he's not working, Daryl tries to avoid making bogeys on the golf course.

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